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KMID : 0043320010240050385
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Archives of Pharmacal Research
2001 Volume.24 No. 5 p.385 ~ p.389
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Synthesis and In Vitro Cytotoxicity of 4-Alkyl- or 4-Arylaminosubstituted Cyclopenta[c]quinoline Derivatives
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Lee Hee-Soon
Lee Jee-Man
Yang Sung-Il
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Abstract
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Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds 6c and 6e bearing p-anisidine and pyrrolidine side chain were more active than the others.
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KEYWORD
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Antitumor agents, Cyclopentaquinoline derivatives, Cytotoxic activity, Doxorubicin, and TAS-103
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